What is MOTS-c?
MOTS-c is a short peptide encoded within mitochondrial DNA. Its discovery helped expand an emerging area of biology involving mitochondrial-derived peptides.
Why is MOTS-c interesting?
Researchers have investigated MOTS-c in areas involving metabolic homeostasis, cellular stress responses, glucose metabolism, AMPK-associated signalling, mitochondrial communication and age-related biological processes. Much of this research remains experimental.
Mitochondrial-derived peptides
MOTS-c belongs to a broader family of mitochondrial signalling peptides that includes humanin and related molecules.
Evidence status
Mechanistic research is rapidly developing. Animal research is significant. Human biology research is emerging.