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Tissue & Regenerative Biology Research

TB-500 & Thymosin Beta-4 Research

Thymosin beta-4 is a naturally occurring 43-amino-acid peptide investigated in cell migration, angiogenesis and wound biology.

Evidence status

Human evidence: limited depending upon application.

What is Thymosin Beta-4?

Thymosin beta-4 is a naturally occurring 43-amino-acid peptide present in numerous mammalian tissues. It interacts strongly with actin, an essential component of the cellular cytoskeleton.

What has research investigated?

Experimental research has explored cell migration, formation of new blood vessels, keratinocyte activity, inflammatory signalling, cardiac tissue, corneal biology and wound models.

TB-500 terminology

The term TB-500 is frequently used online in connection with synthetic fragments or preparations related to thymosin-beta-4 research. These should not automatically be treated as scientifically interchangeable.

Evidence status

Cellular evidence is extensive and animal evidence is substantial. Human evidence is considerably more limited depending upon application.